Fetal hepatic mesenchymal hamartoma: A case report

fatma douik, Ahlem BLEL, Nadia BEN JAMAA, Imen KSIBI, Radhouane ACHOUR, Anas BESBES, Samia Kacem, Soumeya SIALA GAIGI, Aida MASMOUDI

Abstract


Hepatic tumors accounted 5% of congenital neoplasms. Mesenchymal hamartoma of the liver is a rare benign tumor of children, which definitive diagnosis during the fetal period remains difficult, despite advances in antenatal imaging. In this paper, we report a case of hepatic mesenchymal hamartoma diagnosed prenatally with ultrasound scan showing a multicystic mass in the left upper abdomen accompanying polyhydramnios and complicated by a preterm labor. The newborn died on the first day of life due to respiratory distress and neonatal jaundice. The diagnosis was confirmed histologically post-delivery.


Keywords


Hepatic mesenchymal hamartoma; fetal ultrasound scan; prenatal diagnosis.

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References


Edmondson H. Differential diagnosis of tumors and tumor-like lesions of liver in infancy and childhood. Am J Dis Child .1956;91:168-86.

Stringer MD, Alizai NK. Mesenchymal hamartoma of the liver: a systematic review. J Pediatr Surg. 2005;40(11):1681-90.

von Schweinitz D. Neonatal liver tumours. Semin Neonatol. 2003;8(5):403-10.

Chiorean L, Cui XW, Tannapfel A, Franke D, Stenzel M, Kosiak W, et al. Benign liver tumors in pediatric patients - Review with emphasis on imaging features. World J Gastroenterol. 2015;21(28):8541-61.

Kodandapani S, Pai MV, Kumar V, Pai KV. Prenatal diagnosis of congenital mesenchymal hamartoma of liver: a case report. Case Rep Obstet Gynecol. 2011;2011:932583.

Tsao K, Hirose S, Sydorak R, Goldstein RB, Machin GA, Albanese CT, et al. Fetal therapy for giant hepatic cysts. J Pediatr Surg. 2002;37(10):E31.

Laberge JM, Patenaude Y, Desilets V, Cartier L, Khalife S, Jutras L, et al. Large hepatic mesenchymal hamartoma leading to mid-trimester fetal demise. Fetal Diagn Ther. 2005;20(2):141-5.

Leung JWT, Coakley FV, Hricak H, Harrison MR, Farmer DL, Albanese CT, et al. Prenatal MR Imaging of congenital diaphragmatic hernia. AJR. 2000;174:1607–12.

Isaacs H Jr. Fetal and neonatal hepatic tumors. J Pediatr Surg. 2007;42(11):1797-803.

Cignini P, Coco C, Giorlandino M, Bagolan P, Morini F, Giorlandino C. Fetal hepatic mesenchymal hamartoma: a case report. J Prenat Med. 2007;1(3):45-6.

Cornette J, Festen S, van den Hoonaard TL, Steegers EA. Mesenchymal hamartoma of the liver: a benign tumor with deceptive prognosis in the perinatal period. Case report and review of the literature. Fetal Diagn Ther. 2009;25(2):196-202.

Dickinson JE, Knowles S, Phillips JM. Prenatal diagnosis of hepatic mesenchymal hamartoma. Prenat Diagn. 1999;19(1):81-4.

Kamata S, Nose K, Sawai T, Hasegawa T, Kuroda S, Sasaki T, et al. Fetal mesenchymal hamartoma of the liver: report of a case. J Pediatr Surg. 2003;38(4):639-41.

George JC, Cohen MD, Tarver RD, Rosales RN. Ruptured cystic mesenchymal hamartoma: An unusual cause of neonatal ascites. Pediatr Radiol. 1994;24:304-5.

Bejvan SM, Winter TC, Shields LE, Brock BV, Nghiem HV, Schmiedl UP, et al. Prenatal evaluation of mesenchymal hamartoma of the liver: Gray scale and power Doppler sonographic imaging. J Ultrasound Med. 1997;16:227-9.