Audiological profile in osteoporosis

Bhavya M


Osteoporosis is a multifactorial  disease  characterized  by  decrease  in  Bone mineral density and disruption of bony architecture. This reduction in bone mineral density is measured using T score. T score of <-1 is normal, -1to -2.5 is osteopenic and >-2.5 is osteoporotic. The association between osteoporosis and hearing loss is unknown due to limited studies. The present study was undertaken to study the relation between hearing loss and osteoporosis. 33 postmenopausal indian women in the age range of 38-55 were subjected to Bone mineral density study and T scores were obtained. Based on the T scores participants were divided into three groups. Group I consisted of 12 normals, Group II consisted of 11 Osteopenic women and Group III consisted of 10 Osteoporotic women. Pure tone audiometry, tympanometry and distortion product Otoacoustic emissions were carried out. Data obtained were subjected to statistical analysis and was found that the mean threshold at all frequencies from 250Hz to 8 KHz were better for normal, poorer for osteopenic group and even poorer for osteoporotic group. At all frequencies the effect of reduced BMD on hearing loss was significant. Results indicated that thresholds at all frequencies and pure tone average thresholds were significantly different between the three groups with p<0.05. ‘A’ type of tympanogram was present in all the groups. DPOAE amplitudes were significantly different at 3 KHz and 4 KHz between normal, osteopenic and osteoporotic group with p<0.05. However, there was no significant difference between the groups at 1 KHz and 2 KHz. Osteoporotic group showed a greater number of individuals with sensorineural hearing loss. The present study indicates a stronger relation between osteoporosis and hearing loss. Effect of osteoporosis on auditory system using this test battery indicated bilateral sensorineural hearing loss.

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American National Standard Institute (1991). Maximum Ambient Noise Levels for Audiometric Test Rooms. (ANSI S3.1-1991). New York: American National Standards Institute.

Babich, M., Hoffmeister, D. & Doughty, A. (2009). Osteoporosis and Conductive Hearing Loss: A Novel Model of Clinical Correlation. PHILICA.COM Article number 148.

Carhart,R., & Jerger,J. F. (1959). Preffered method for clinical determination of puretone thresholds. Journal of Speech and Hearing Research,24:330

Henkin RI, Lifschitz MD, Larson AL (1972). Hearing loss in patients with osteoporosis and Pagets disease of bone. Am J Med Sci; 263: 383-392.

K. C. Horner. (2009). The effect of sex hormones on bone metabolism of the otic capsule—an overview, Hearing Research, 252: 56–60.

Kim SH, Kang BM, Chae HD, Kim CH (2002). The association between serum estradiol level and hearing sensitivity in postmenopausal women. Obstet Gynecol 99:726–730.

Lee JH, Marcus DC (2001). Estrogen acutely inhibits ion transport by isolated stria vascularis. Hear Res 158:123–130.

Maurer P, Hohenester E, Engel J. (1996) Extracellular calcium-binding proteins. Curr Opin Cell Biol, 8:609-617.

Shafer,D.N.,(2006,August 15)Researchers Investigate Link Between Hearing loss and Osteoporosis TheASHALeader.htto://

Stenberg AE, Wang H, Fish J III, Schrott-Fischer A, Sahlin L, Hultcrantz M (2001.) Estrogen receptors in the normal adult and developing human inner ear and in Turner’s syndrome. Hear Res 157(1–2):87–92

Stover, L., Gorga, M. P., Neely, S. T., and Montoya, D. (1996) ‘‘Toward optimizing the clinical utility of Distortion Product Otoacoustic Emission Measurements,’’ J. Acoust. Soc. Am. 100:956–967.

World Health Organization (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: Report of a WHO study group. WHO Technical Report Series 843:1-129.